Toward the end of the chapter, when Isaac went to test fire the engines of the shuttle in the Executive Shuttle Hangar Bay, the Hunter once again revealed itself and attempted to kill him. The creature chased Isaac throughout the Crew Deck, first in the central room where Marker 3A was located before following him to the bunk rooms. The Hunter reappeared in Chapter 10, after Dr. However, the creature was eventually thawed and once again began stalking Isaac, confronting and pursuing him once again on the Mining Deck in Chapter 7 before the engineer escaped. Isaac finally faced it down in the Cryogenic Lab where he managed to freeze the creature inside a cryogenic tube, supposedly taking care of the problem once and for all. The creature stalked Isaac throughout the chapter as he attempted to complete his objectives.

Isaac eventually escaped after learning about the creature's regenerative abilities. Mercer awoke the creature in an attempt to kill Isaac. Challus Mercer kept the creature stored in a stasis tube in the Chemistry Lab on the Medical Deck, just outside the Cryogenics Storage Room. The Hunter first appeared during Chapter 5: Lethal Devotion.

The Hunter breaks free of its stasis tube. The spine and the pelvis bone could be seen at the back. Pieces of different bones could be seen pointing at different body parts. The body was greatly covered in muscular tissue with no original skin left due to the mutation. The big toes were severely enlarged into sharp claws.

The victim's jaw was gone with four tentacle-like veins hanging in its place, along with the neck frozen into a 45-degree angle. Just like the other Regenerating and Enhanced Necromorphs, the Hunter's eyes glowed, although not as strongly as the other Regenerators'. The Hunter's voice could be compared to a deep throaty roar as opposed to the Slasher's usual form of screaming and shouting. Unlike the other forms of Necromorphs, it was able to regenerate lost limbs in seconds, meaning that conventional dismemberment tactics only served to temporarily incapacitate it. It was noticeably bulkier and taller than the standard Slasher and its original arms appeared to be bound inside the flesh of its torso similar to a straitjacket. The Hunter physically resembled a Slasher, possessing large blades that were attached to a pair of elongated arms jutting out from its shoulder blades.

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